SS-31

SS-31 Injectable

SS-31 (40mg) Injectable

Category: Energy & Mitochondrial Health

SS-31, also known as Elamipretide, is a mitochondria-targeted tetrapeptide that improves mitochondrial function. It works by interacting with cardiolipin, a vital phospholipid found on the inner mitochondrial membrane. This interaction stabilizes mitochondrial structure, increases energy production, and reduces oxidative stress.

Extensive research has explored SS-31's potential in treating various conditions, including age-related diseases, muscle wasting, age-related macular degeneration, heart failure, chronic kidney disease, and chemotherapy-induced muscle wasting.


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3-Pack Bundle $1,500

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Frequently Asked Questions

  • BENEFITS

    • Enhanced Cellular Energy and Repair: SS-31 boosts ATP production, crucial for cellular repair and high-energy demands. This is especially valuable in conditions like ischemia, where it aids in ATP recovery and mitochondrial efficiency for survival and healing.
    • Muscle Preservation: Demonstrates promise in counteracting muscle wasting due to cancer, chronic illnesses, and chemotherapy. SS-31 improves muscle energy, reduces catabolism, and safeguards against mitochondrial damage, thereby supporting muscle mass retention and physical endurance.
    • Improved Cognitive Function: By strengthening synaptic integrity and lowering neuroinflammation, SS-31 enhances memory and synaptic function, making it a potential therapeutic for neurodegenerative disorders.
    • Reduced Oxidative Damage: SS-31 minimizes the production of reactive oxygen species (ROS), stabilizing mitochondrial membranes and shielding vital tissues such as the heart, skeletal muscle, and kidneys from oxidative stress.
    • Cardiovascular and Ocular Support: It has been shown to improve cardiovascular health and enhance visual acuity in age-related macular degeneration, particularly improving low-luminance vision, which can significantly improve the quality of life for individuals with impaired sight.

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  • CONTRAINDICATIONS

    • Pregnancy and Breastfeeding: The safety of NAD⁺ for pregnant or breastfeeding women has not been established.
    • Active Cancer: Exercise caution when considering SS-31 for patients with active cancer, as it may boost cellular metabolism and energy production. 
    • Only use under the guidance of a healthcare provider.

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  • POTENTIAL SIDE EFFECTS

    • Injection Site Reactions: Mild redness, itching, or discomfort may occur at the injection site. Rotating the injection site can help minimize these symptoms.
    • Headache and Dizziness: These have been reported, possibly due to increased mitochondrial activity and altered blood flow.
    • Mild Gastrointestinal Distress: Nausea or stomach discomfort may occur, especially at higher doses, but these symptoms are usually mild and temporary.
    • Flushing and Fatigue: Users may experience flushing similar to that caused by niacin, along with temporary fatigue as the body adapts to increased mitochondrial function.
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  • TIPS TO REDUCE SIDE EFFECTS

    • Start with a Low Dose: Begin with a smaller dose and gradually increase it to minimize potential side effects such as nausea and headaches.
    • Vary Injection Sites: Rotate injection locations to prevent irritation and pain in any single area.
    • Maintain Hydration: Ensure adequate water intake to help reduce headaches and flushing, as proper hydration supports mitochondrial function.
    • Administer with Food: If you experience gastrointestinal discomfort, taking SS-31 with food may help alleviate these symptoms.
    • Consult a Healthcare Provider: Regular professional monitoring is recommended to ensure safe and effective use.
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  • HOW IT WORKS

    • SS-31 plays a crucial role in maintaining mitochondrial health and function. By binding to cardiolipin, it preserves the structural integrity of mitochondrial cristae and membranes, thereby preventing mitochondrial swelling and dysfunction. This action enhances ATP production and mitigates oxidative damage through the inhibition of cytochrome c peroxidase activity.
    • Furthermore, SS-31 downregulates Fis1, a mitochondrial fission protein, which offers protection against cellular damage during inflammation. This helps to reduce apoptosis and sustain energy production. 
    • Ultimately, this stabilization leads to improved mitochondrial efficiency, enhanced energy metabolism, and reduced oxidative stress, particularly in tissues susceptible to mitochondrial dysfunction.

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  • EXPECTED EFFECTS

    • 1-2 Weeks: Users often report initial improvements in energy levels, reduced muscle soreness, and enhanced endurance. Increased mitochondrial efficiency can also lead to reduced fatigue, especially after physical activity.
    • 4-6 Weeks: Noticeable benefits in cognitive performance and visual function may be observed. Users often report enhanced memory, focus, and low-luminance vision, particularly beneficial for those with age-related macular degeneration.
    • 8-12 Weeks: Significant improvements in muscle mass, reduced oxidative stress, and enhanced cardiovascular health are typical. Consistent use leads to long-term mitochondrial benefits, reduced muscle wasting, and improved quality of life.
    • Long-term: Continuous use of SS-31 supports mitochondrial health, enhances muscle endurance, and maintains cognitive function, leading to better overall energy levels and reduced disease-related symptoms.