Metformin

What Is Metformin?

Metformin is a prescription medication widely used to support metabolic health. Originally developed to manage blood glucose levels in individuals with insulin resistance, it has also been shown to aid in weight management, particularly for people with impaired glucose metabolism, prediabetes, or hormonal imbalances that affect body composition.

How Metformin Works

Metformin supports healthy weight regulation by improving the way your body processes and uses energy:

• Enhances insulin sensitivity: Helps your cells absorb glucose more efficiently, reducing insulin resistance and lowering blood sugar levels.
  
• Reduces fat storage: Encourages the body to use glucose and fat for energy rather than storing it.
  
• Balances appetite signals: May reduce hunger and cravings by stabilizing blood sugar fluctuations.
  
• Improves gut microbiome activity: Positively influences gut bacteria, which can support metabolic efficiency.
  

Supports steady energy: Prevents blood sugar highs and lows, helping maintain consistent energy throughout the day.

Who It’s For

Metformin may be appropriate for individuals who:

• Experience slow metabolism, fatigue, or cravings related to blood sugar fluctuations
  
• Have insulin resistance, prediabetes, or PCOS (polycystic ovary syndrome)
  
• Seek steady, moderate weight loss without stimulants
  
• Want to improve metabolic health as part of a physician-guided program
  
• Are using GLP-1/GLP-2 or peptide therapies and would benefit from additional metabolic support

Your provider will evaluate your health history, lab results, and goals before prescribing Metformin.

Benefits of Metformin for Weight Management

• Supports steady, moderate fat loss
  
• Enhances energy balance and endurance
  
• Stabilizes appetite and cravings
  
• Promotes healthier insulin function
  
• Complements GLP-based or peptide therapies for more comprehensive results
  
• Safe, non-stimulant option suitable for long-term use under medical guidance

Results vary.

Your Metformin Protocol at Nexa

• Comprehensive Evaluation – We review your health history, lifestyle, and lab markers related to metabolism and insulin sensitivity.
  
• Personalized Dosing Plan – We start with a low dose to ensure tolerance, then adjust based on response and goals.
  
• Integrative Strategy – Metformin may be combined with GLP-1, GLP-2, or peptide therapies for enhanced outcomes.
  
• Ongoing Monitoring – Regular check-ins to track progress, adjust dosing, and monitor labs as needed.
  
• Long-Term Optimization – Once your metabolism is balanced, we transition into maintenance and prevention strategies.
  

Metformin vs. GLP-1 Therapies

• Metformin: Improves insulin sensitivity, glucose metabolism, and overall energy balance—ideal for foundational metabolic health.
  
• GLP-1/GLP-2 (e.g., semaglutide, tirzepatide): Mimic natural hormones that reduce appetite and promote fat loss.
  

Together: These therapies can work synergistically—Metformin supporting cellular energy use, and GLP-based medications managing appetite and nutrient regulation.