Contrave

What Is Contrave?

Contrave is a prescription weight management medication that combines two active ingredients—bupropion and naltrexone—to help control appetite and reduce food cravings. Together, they work on the brain’s appetite and reward centers to make it easier to eat mindfully, reduce emotional eating, and sustain healthy habits.

How Contrave Works

Contrave acts on two key pathways in the brain that regulate appetite and food reward:

• Bupropion (Wellbutrin): A dopamine and norepinephrine reuptake inhibitor that supports mood balance and helps reduce appetite and food cravings.
  
• Naltrexone: Modulates the reward system to reduce the desire for food-related pleasure and limit overeating triggers.
  

Together, these mechanisms help you regain control over hunger signals—making portion control, consistency, and mindful eating feel natural and sustainable.

Who It’s For

Contrave may be an effective option if you:

• Struggle with cravings or emotional eating
  
• Experience stress-related or habitual snacking
  
• Want to support appetite regulation without stimulants
  
• Are looking for an FDA-approved oral option for weight management
  
• Are interested in combining medication with lifestyle support for better long-term results
  

Your provider will assess your medical history, current medications, and goals to determine whether Contrave is appropriate for you.

Benefits of Contrave for Weight Loss

• Reduces cravings and impulsive snacking
  
• Supports emotional balance and mood regulation
  
• Helps promote consistent calorie control
  
• Enhances focus and motivation around healthy habits
  
• Complements GLP-1 or peptide-based therapies for enhanced outcomes
  
• Non-stimulant, making it suitable for clients sensitive to traditional weight-loss medications Results vary.
  

Your Contrave Program at Nexa

• Comprehensive Evaluation: A personalized consultation with a Nexa clinician to review your health history, goals, and lifestyle factors.
  
• Tailored Treatment Plan: A phased dosing schedule customized to your comfort and response, often combined with nutrition and lifestyle guidance.
  
• Ongoing Support & Monitoring: Regular follow-ups to track progress, assess tolerance, and adjust your plan as needed for optimal results.
  
• Combination Strategy: When appropriate, Contrave can be paired with GLP-1, GLP-2, or metabolic therapies for comprehensive weight management.
  

Contrave vs. Other Medical Weight Loss Therapies

• Contrave: Targets cravings, reward-based eating, and appetite control through central nervous system pathways.
  
• GLP-1/GLP-2 (Semaglutide, Tirzepatide): Targets appetite and metabolic regulation via gut hormone pathways.
  
• Metformin or Topiramate: Support insulin sensitivity and metabolic balance.

Best results are achieved when these therapies are integrated strategically based on your physiology, preferences, and long-term goals.