Topiramate

What Is Topiramate?

Topiramate is a prescription medication originally developed for neurological conditions. In weight management, it’s used to help reduce appetite and improve satiety. It is also one of the components in an FDA-approved combination therapy for chronic weight management. At Nexa, Topiramate may be prescribed alone or in combination with other therapies when clinically appropriate.

How It Works

Topiramate supports weight loss through multiple pathways that influence eating behavior and metabolic balance:

• Appetite & craving control: Modulates neurotransmitter activity linked to hunger and reward.
  
• Increased satiety: Helps you feel satisfied sooner and stay satisfied longer.
  
• Taste perception changes: May reduce desire for certain calorie-dense foods and sweetened beverages.
  

Metabolic support: Carbonic anhydrase inhibition may contribute to reduced caloric intake over time.

Who It’s For

Topiramate may be a good option if you’re seeking:

• Better control over evening or stress-related snacking
  
• Support for portion control and reduction of cravings
  
• A non-stimulant adjunct to GLP-1/GLP-2 therapies (e.g., semaglutide, tirzepatide)
  
• A personalized, measured approach to sustainable weight loss
  

Eligibility is determined during a clinician consultation and review of your health history and labs.

Benefits Clients Notice

• Reduced cravings and improved portion control
  
• Steadier energy with fewer highs/lows from grazing
  
• Support for fat loss when paired with nutrition and activity
  
• Flexible integration with GLP injectables or oral options
  
• Physician oversight for precision dosing and safety
  

Results vary. Best outcomes occur with consistent lifestyle support (nutrition, movement, sleep, stress).

Your Topiramate Protocol at Nexa

• Clinical Consult & Labs – We assess goals, medical history, medications, and relevant biomarkers.
• Start Low, Go Slow – Gradual titration to a well-tolerated, effective dose; no “one-size-fits-all.”
  
• Integrated Plan – Option to combine with GLP-1/GLP-2 therapies and coaching for synergy.
• Ongoing Optimization – Regular check-ins, side-effect review, and data-driven adjustments.
• Tapering Strategy – If/when discontinuing, we taper to reduce rebound effects.
  

Topiramate vs. GLP-Based Therapies

• Topiramate: Strong on craving and portion control; non-stimulant; can complement GLP therapies.
  
• GLP-1/GLP-2 (e.g., semaglutide, tirzepatide): Strong on appetite, satiety, and glycemic balance; weekly injectable or daily oral options.

Best results often come from a personalized combination, guided by your clinician and your data.