MK-677

• Increases Growth Hormone and IGF-1 Levels: MK-677 naturally stimulates the release of growth hormone and IGF-1, promoting overall vitality, recovery, and longevity without the need for injections.
• Enhances Muscle Growth and Strength: By supporting protein synthesis and muscle repair, MK-677 helps increase lean muscle mass and improve physical performance.
• Improves Recovery and Repair: Higher growth hormone levels aid in faster healing of injuries, better post-exercise recovery, and reduced muscle soreness.
• Boosts Sleep Quality: MK-677 is known to improve deep (REM) sleep cycles, helping restore energy, focus, and hormonal balance.
• Supports Fat Metabolism: By increasing metabolism and muscle mass, it helps the body utilize fat more efficiently, aiding in long-term weight management and body recomposition.
• Promotes Healthy Skin, Hair, and Nails: Enhanced collagen production contributes to smoother skin, improved elasticity, and overall youthful appearance.
• Protects Bone Density: Long-term use supports stronger bones and joint health by improving bone mineral density—especially beneficial as we age.
• Non-Suppressive and Convenient: MK-677 boosts hormone production naturally, without suppressing the body’s own growth hormone output, and is conveniently taken in oral form.

• Pregnant or breastfeeding women, as safety has not been established.
• Individuals with active cancer or a history of growth hormone–sensitive tumors, since increased GH and IGF-1 levels may stimulate abnormal cell growth.
• Patients with uncontrolled diabetes or severe insulin resistance, as MK-677 can elevate blood glucose and insulin levels.
• Individuals with severe heart, liver, or kidney disease, where fluid retention may exacerbate symptoms.
• Anyone with a known allergy or hypersensitivity to MK-677 or its components.

• Increased Appetite: A temporary rise in hunger, particularly in the early stages of treatment.
• Water Retention or Mild Edema: Some users may notice puffiness in the hands, feet, or face due to fluid retention.
• Muscle or Joint Soreness: Mild stiffness or discomfort can occur as tissues respond to enhanced growth hormone activity.
• Transient Fatigue or Lethargy: Some individuals may feel tired or sluggish during the adjustment period.
• Numbness or Tingling (Carpal Tunnel–Like Symptoms): Rare but possible with elevated growth hormone levels.
• Elevated Blood Sugar or Insulin Resistance: MK-677 may slightly increase fasting glucose or insulin levels in susceptible individuals.
• Mild Headaches: Occasionally reported, especially at higher doses or with dehydration.

• Start Low and Increase Gradually: Begin with a lower dose to allow your body to adapt to increased growth hormone and IGF-1 levels. Gradual titration helps reduce the likelihood of side effects such as water retention, fatigue, or muscle stiffness.
• Stay Well Hydrated: Proper hydration supports kidney function and helps reduce bloating or mild edema that can occur during treatment.
• Maintain a Balanced Diet: Eat nutrient-dense meals with lean proteins, healthy fats, and complex carbohydrates to stabilize blood sugar and counteract potential increases in appetite. Avoid excessive sugar intake to minimize insulin resistance.
• Monitor Blood Sugar and IGF-1 Levels: Regular lab monitoring ensures optimal dosing and helps your provider adjust your treatment plan if glucose or growth hormone markers rise above ideal ranges.
• Support Sleep and Recovery: Because MK-677 enhances growth hormone secretion during sleep, prioritize 7–9 hours of quality rest each night. Adequate recovery time enhances results while reducing fatigue and soreness.
• Stay Active: Incorporating light exercise or mobility work improves circulation, reduces fluid retention, and supports lean muscle development.
• Follow Physician Guidance: Always take MK-677 exactly as prescribed. If side effects persist or worsen, contact your Nexa provider—most issues can be easily managed by adjusting dosage or timing.

• MK-677 (Ibutamoren) works by mimicking the action of ghrelin, a naturally occurring hormone that stimulates appetite and triggers the release of growth hormone (GH) from the pituitary gland. When taken orally, MK-677 binds to ghrelin receptors in the brain, signaling the body to increase both growth hormone and insulin-like growth factor 1 (IGF-1) production.
• These two hormones play a crucial role in cell growth, repair, metabolism, and recovery. Higher GH and IGF-1 levels lead to increased protein synthesis, better tissue regeneration, and improved muscle and bone density. Unlike direct growth hormone injections, MK-677 stimulates the body’s own natural hormone production, maintaining balance without shutting down endogenous GH output.
• Additionally, MK-677 supports deep sleep cycles and enhances metabolic efficiency, allowing for better recovery, body composition improvements, and overall vitality. By optimizing these key hormonal pathways, MK-677 helps the body restore a more youthful, high-functioning metabolic state—naturally and safely.

Weeks 1–2: Adjustment Phase

You may notice increased appetite, improved sleep quality, and mild water retention as your body begins to respond.

Some individuals report deeper, more restorative rest and subtle boosts in energy or recovery.

Weeks 3–4: Early Benefits

Enhanced recovery after workouts or physical activity becomes noticeable.

Muscle fullness and hydration may improve due to elevated growth hormone and IGF-1.

Sleep continues to deepen, and many patients report waking up more refreshed.

Weeks 5–8: Visible and Functional Changes

Increased lean muscle mass and gradual fat reduction become evident.

Skin elasticity and tone may improve as collagen production rises.

You may feel stronger, more energetic, and experience improved mood and focus.

Weeks 8–12 and Beyond: Long-Term Optimization

Continued improvements in muscle definition, body composition, and recovery time.

Noticeable enhancements in joint comfort, bone density, and overall vitality.

Skin, hair, and nails often appear healthier and more youthful.

Benefits stabilize as hormone levels reach a new balanced baseline.

Long-Term Use: 

With consistent, physician-guided use, MK-677 supports sustained growth hormone optimization, helping maintain muscle tone, energy, and recovery as part of a long-term wellness or performance plan.